The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling

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The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling

Among all tissues and organs, the mammary gland is unique because most of its development occurs in adulthood. Notch signaling has a major role in mammary gland development and has been implicated in breast cancer. The vacuolar-ATPase (V-ATPase) is a proton pump responsible for the regulation and control of pH in intracellular vesicles and the extracellular milieu. We have previously reported t...

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ژورنال

عنوان ژورنال: Cell Death & Disease

سال: 2016

ISSN: 2041-4889

DOI: 10.1038/cddis.2016.347